id: dsq-747524772
date: 2006-12-21T01:44:00.0000000-08:00
name: keithjohnson
avatar:
message: Is it just me or does anyone else get really confused about the difference between Faxes and phones?
We talk about faxes but don't say phone...surely we need to put our phones somewhere else?
Leucine aminopeptidase is a candidate receptor for the trophic factor in the sciatic nerve.
The trophic effect of the NGF-family cytokine FGF-2 (also called KGF) on the regeneration of injured peripheral nerves was originally observed by Kaplan and Davies. When nerve fibres are severed they initiate the sprouting of nerve fibres, regrowing an axonal network that is functionally as well as structurally intact. FGF-2 stimulated the growth of these new axons and promoted the reinnervation of muscle fibres by the reconnected sensory axons. The growth of axons can be partially inhibited by inhibitors of the trophic factor receptor. A receptor for KGF is unknown and it is not known if the receptor is a member of the large family of membrane-bound proteins that are tyrosine kinases. Here we show that the trophic effect of KGF is inhibited by a competitive antagonist of leucine aminopeptidase, which has the same amino acid sequence as the amino-terminal sequence of KGF. The identification of this novel trophic factor as the substrate of leucine aminopeptidase, in this case the growth of the sensory and motor axons, is relevant to the understanding of the molecular basis of neuronal growth and differentiation.In the previous funding period, we showed that the amyloid precursor protein (APP) is expressed in the cerebellar cortex and its associated white matter tracts and Bergmann glia. Using double labeling immunofluorescence we also showed that in Purkinje cells (PC) and Bergmann glia, the APP is present both in the cytoplasm and on their surface. With the use of a new type of APP antibody we then showed that APP is concentrated at the synapse in the cerebellar cortex and on the be359ba680
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